More than one quarter of the epilepsy-related genes encode ion channel proteins, including the ligand-gated ion channels (such as gamma-aminobutyric acid receptors, N-methyl-D-aspartate receptors and nicotinic acetylcholine receptors) and the voltage-gated channels (such as Ca2+, K+ and Na+ channels) [25]. The gene discussed is GLRA3; the disease is epilepsy.