POU5F1 and myocardial infarction: To further assess the roles of Oct4-c-Myc in mediating the response of cMSCs to local signals in the injured heart, we injected cMSCs pre-treated with lentiviral vectors encoding Oct4 (oeOct4), Oct4 siRNA (siOct4), vehicle, or in combination with c-Myc siRNA (sic-Myc) or c-Myc overexpression (oec-Myc) were randomly transplanted into the hearts of recipient rats subjected to acute MI.