JHG could also ameliorate pathological changes and collagen deposition in bleomycin-induced pulmonary fibrosis rats [23], and inhibited NADPH oxidase 4 (NOX4) levels and increased the nuclear factor erythroid 2-related factor 2 (Nrf2) in lung tissues could also be found. The gene discussed is NFE2L2; the disease is pulmonary fibrosis.