For example, FNDC3A can bind FAM46C to inhibit multiple myeloma progression by regulating autophagy [18], and FNDC5 regulates the conversion of white fat to brown fat [19, 20] and improves insulin resistance by regulating the macrophage polarization, thereby reducing the validation response of adipose tissue [21]. The gene discussed is FNDC3A; the disease is plasma cell myeloma.