VEGFA and sarcoma: Modern pharmacological studies have found that the Coix seed can achieve direct anti-tumor and immune regulation through multi-target and multi-channel synergy, such as inhibiting tumor growth by down-regulating the expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) protein to block the angiogenesis of S180 sarcoma, and its inhibition rate (IR) reached 46.21% [5].