The production of BAFF is associated with type I IFNs when viruses, including SARS-CoV-2, invade cells such as monocytes, macrophages, and dendritic cells [22, 25, 26] but there are heterogeneous IFN-α profiles reported in COVID-19 patients [26, 27]. The gene discussed is TNFSF13B; the disease is COVID-19.