Moreover, 58 differentially regulated transcripts identified in this study overlapped candidates from three gene expression studies of MDD [45, 109] (Supplementary Tables TS24), a vast majority of which were altered in multiple regions beyond the single region profiled in the respective human studies (e.g. Arhgef25, Kmt2a, Mettl9, Rhoa, Mgat4c). Here, ARHGEF25 is linked to major depressive disorder.