CHMP5 and COVID-19: Whether other timeline of I/R injury (e.g., I/R happened shortly before vaccination or concurrently with vaccination) would affect heart repair warrants further exploration; 2) only Ad5-vector vaccine is included and alternative types of COVID-19 vaccines that deliver the spike protein with various modifications should be examined similarly in the follow-up studies; 3) I/R is the only examined disease of heart injury and the animal number size is still relatively small.