Our previous studies showed that the pro-inflammatory Wnt5a/anti-inflammatory sFRP5 system is closely related to various acute (e.g. sepsis7) as well as chronic (e.g. psoriasis13) inflammatory diseases and is also important in the context of metabolic inflammation in obesity and type 2 diabetes. Here, SFRP5 is linked to obesity due to melanocortin 4 receptor deficiency.