However, whilst the SV2A findings could reflect a selective loss of synaptic terminals, or even just vesicle proteins, in schizophrenia, when they are taken with the post-mortem evidence for lower levels of pre- and postsynaptic markers in the same regions in schizophrenia, the most likely interpretation is that they reflect lower synaptic density in the disorder. The gene discussed is SV2A; the disease is schizophrenia.