In addition, it had been shown that levosimendan ameliorated myocardial infarction and ventricular remodeling in diabetic rats, and the expression of the gene Plekhf1 received regulation by levosimendan, showing the potential of Plekhf1 as a target gene for myocardial infarction and diabetic cardiomyopathy28. The gene discussed is PLEKHF1; the disease is myocardial infarction.