AKT1 and familial dilated cardiomyopathy: In addition, we performed a functional enrichment analysis of the pathogenesis of DCM and related molecular pathways and found that AR-DEGs of DCM were mainly enriched in autophagy regulatory pathways and cell growth signaling, such as regulation of autophagy, macroautophagy, AMPK signaling pathway, PKB-mediated events, etc. AMPK (Adenosine monophosphate-activated protein kinase) signaling pathway had been reported to be an important intracellular signaling pathway in the heart63.