CD4+ T cells can differentiate into anti-inflammatory subtypes, such as Type 2 helper (Th2) cells, and pro-inflammatory subtypes, such as Type 1 helper (Th1) cells and Type 17 helper (Th17) cells; T regulatory cells (Tregs) are one necessary CD4+ T subtypes in preventing autoimmunity. The gene discussed is CD4; the disease is Autoimmunity.