We confirmed with a H-score for the IHC Elovl5 staining that the average expression of Elovl5 was downregulated in breast cancer (T) tissue compared to adjacent normal (NT) breast tissue and was higher in ER+ breast cancer samples than in ER− breast cancer tissues (Her2+ and TNBC) (Fig. 1D and Supplementary Table S2). Here, ESR1 is linked to breast cancer.