AKT1 and familial pancreatic carcinoma: Canonical pathways that were inhibited with TSA include cell cycle/division pathways such as cell cycle control of chromosomal replication and kinetochore metaphase signaling pathway as well as ADM-promoting pathways such as PI3K/AKT [18] and those associated with pancreatic cancer (e.g., Spink1) (Fig. 9B).