GSK3B and liver cancer: For example, Toosendanin (TSN), a novel WW Domain Containing Oxidoreductase (WWOX) candidate agonist, has significant anti-proliferative and anti-metastatic effects on liver cancers, and functions by accelerating the degradation of β-catenin by promoting the activity of the degradation complex components including APC, AXIN1, CK1 and the GSK3β complex [34].