By the histological analysis, hepatic CSCs markers CD133 and CD44 were downregulated accompanied with the induction of cell apoptosis and the blockade of neovascularization in HCC tissues after Ad-LECT2 gene therapy, and it has been reported that LECT2 can antagonize VEGFR2 receptor activation to inhibit angiogenesis in HCC (18). This evidence concerns the gene CD44 and hepatocellular carcinoma.