By rescaling the genetic associations to the PHI-induced effects of genetically predicted therapeutic rises in endogenous EPO levels, the odds of disease were 1.01 (95% CI = 0.93, 1.07) for CAD, 0.99 (95% CI = 0.87, 1.15) for MI, and 0.97 (95% CI = 0.87, 1.07) for stroke (Figure 4, Table S13). Here, EPO is linked to Stroke.