Using these very large sample sizes, we found no evidence (at p < 0.05) of a genetic association between 1 SD higher endogenous EPO levels (equivalent to 5.1 IU/L) and increased odds of CAD (odds ratio [OR] [95% CI] = 1.03 [0.85, 1.25], p = 0.72), stroke (OR [95% CI] = 0.92 [0.70, 1.21], p = 0.55), or MI (OR [95% CI] = 0.98 [0.75, 1.29], p = 0.89) (Table S12). This evidence concerns the gene EPO and Stroke.