Furthermore, the association between the constitutive block of cells in the G2/M phase with the evident decrease in c‐Myc protein levels underline the critical role of c‐Myc inactivation in cell cycle arrest coordinated by PLK1 inhibition,57 hence emphasizing the potential antiproliferative effect of PLK1 target inhibition in c‐Myc deregulated tumours. This evidence concerns the gene PLK1 and neoplasm.