These genes include “moderate penetrance” breast cancer susceptibility genes such as ATM and CHEK2, mutations in which are associated with a 2‐4‐fold increase in lifetime risk of female breast cancer (Antoniou, 2014; Easton, 2015; LaDuca, 2020; Leedom, 2016; Marabelli, 2016). The gene discussed is CHEK2; the disease is breast cancer.