Schlottmann et al.49provided several possible explanations why EC is more common in obese individuals, including a higher prevalence of gastroesophageal reflux disease, linear associations between central adiposity and BE development; low levels of adiponectin, high serum leptin levels that potentially affect cell proliferation processes and changes in the esophageal microbiota due to unhealthy dietary habits that promote carcinogenesis. The gene discussed is ADIPOQ; the disease is gastroesophageal reflux disease.