By contrast, sacubitril/valsartan did reduce AST and ALT in PARADIGM‐HF, suggesting either a specific effect of neprilysin inhibition on transaminase activity or, more likely, a greater effect of sacubitril/valsartan on preload and afterload, compared with an SGLT2 inhibitor.11 This evidence concerns the gene SLC5A2 and hydrops fetalis.