Alzheimer's disease (AD) mainly presents with memory impairments and accumulations of mixed three‐repeat and four‐repeat (3R + 4R) tau isoforms, while progressive supranuclear palsy (PSP) is noted with motor symptoms and accumulations of 4R tau isoforms.5, 6, 7. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.