In this study, we combined [18F]PM‐PBB3 tau PET with a multi‐atlas method for automatic and accurate identification of brain structures on MRI, and by using brain images of AD and PSP cases as helpful training datasets, we successfully constructed a linear model that could distinguish spatial distributions of AD‐type 3R + 4R and PSP‐type 4R tau depositions in vivo. Here, MAPT is linked to Alzheimer disease.