The high discrimination performance of the machine learning approach applied to the [18F]PM‐PBB3 data can be interpreted as evidence of the specificity of the tracer to bind to different forms of tau fibrils (3R + 4R mixed or 4R) and its ability to localize the different pathological features of AD and PSP. The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.