Moreover, the decreased insulin resistance observed in an integrin α2β1 null rodent may be explained by an enhanced vascularisation in HF‐fed itgα2–/−mice compared to controls as shown using immunostaining techniques (Kang et al., 2011), providing further evidence of the anti‐angiogenic nature of integrin α2β1. The gene discussed is ITGA2; the disease is Insulin resistance.