INS and Insulin resistance: The causes of insulin resistance and reduced insulin‐stimulated glucose uptake in skeletal muscle are complex and likely involve disruptions to (1) glucose delivery, (2) transport across the sarcolemma and (3) glucose metabolism with defects in the intracellular protein networks contributing to failure of the second and third of these processes (Karlsson et al., 2005; Mackenzie & Elliott, 2014; Zick, 2001).