The increase of CD31 in HF‐fed ILKlox/loxHSAcre mice was also associated with a decrease in c‐Jun N‐terminal kinase, P38 and extracellular signal‐regulated kinases 1 and 2, all of which are known to inhibit endothelial function and capillary proliferation, with an increase in insulin‐dependant Akt phosphorylation (Kang et al., 2016). Here, INS is linked to hydrops fetalis.