This model has been widely used both for fundamental research and therapeutics studies as the developing tumors reproduce many features of human neuroblastoma in an immunocompetent background.21 22 TH-MYCN tumors arise spontaneously from sympathetic ganglia, they share most of the genetic abnormalities observed in MYCN-amplified tumors, and show histology and imaging characteristics highly similar to the human disease. This evidence concerns the gene MYCN and neuroblastoma.