Defects in antigen-presenting machinery and low expression levels of MHC class I molecules by neuroblastoma cells have also been reported.19 Very recently, it has been shown that peptide-centric CARs can recognize unmutated tumor peptides across multiple HLA genotypes and that targeting the PHOX2B transcription factor with such CARs induces an upregulation of MHC and killing of neuroblastoma cells in vitro and in animal models.20 This evidence concerns the gene PHOX2B and neuroblastoma.