TP53 and cancer: The KEGG pathway enrichment analysis indicated that up‐regulated mRNAs were enriched in 20 pathways, such as ‘cell cycle’, ‘p53 signaling pathway’ and ‘microRNAs in cancer’, whereas down‐regulated mRNAs were enriched in 14 pathways, consisting of ‘B cell receptor signaling pathway’, ‘cytokine‐cytokine receptor interaction’ and ‘butanoate metabolism’ (Fig. 3C).