We also show that the induction of Acsl1 expression by inflammation is enhanced by hyperglycemia, indicative of an interplay between the CHREBP and NF-kappa B. In support of this, we show increased Acsl1-luciferase reporter activity upon co-expression of CHREBP and NF-kappa B compared to either factor alone. Here, ACSL1 is linked to Hyperglycemia.