In secondary analyses of the EMPA‐REG‐OUTCOME trial and the CANVAS program, changes in markers associated with plasma volume such as haemoglobin, haematocrit and amino‐terminal pro–B‐type natriuretic peptide (NT‐pro BNP) were the most significant mediators of cardiovascular mortality and heart failure hospitalizations.5, 14. Here, NPPB is linked to heart failure.