TGFB1 and Hepatic fibrosis: Due to the importance of TGF-β signaling, ECM synthesis, and HSC transformation in the pathophysiology of liver fibrosis, state-of-the-art antifibrotic strategies that target the ECM [14] and HSCs [15] and stem cell-based therapies [16] that target TGF-β1 [17] and enhance antifibrotic efficacy [18] are currently used to treat liver fibrosis.