Of these 93 overlapping rare variants, the majority (84/93) was identified in genes in the AMD‐associated loci, whereas the remaining nine overlapping variants were identified in complement‐related genes (C1S, CSMD2, CFHR5, CR1, ELANE), lipid‐related genes (LDLR, APOB, ACAT1) or in genes evaluated in mouse models that developed drusen or other AMD characteristics (LDLR, APOB, HTRA1). The gene discussed is C1S; the disease is age-related macular degeneration.