The model recapitulates key clinical features necessary to secure a guideline-based HFpEF diagnosis, such as signs and symptoms of HF, elevated NH2-terminal-prohormone B-type natriuretic peptide (NT-proBNP), left atrium (LA) enlargement and dysfunction, LV hypertrophy and diastolic dysfunction, and pulmonary hypertension, which is present in up to an estimated 80% of patients with HFpEF (1, 8). Here, NPPB is linked to hydrops fetalis.