PROS1 and COVID-19: SARS-CoV-2 binds to angiotensin-converting enzyme 2 receptors and undergoes S protein priming by the type II transmembrane serine protease (TMPRSS2) to enter cells.35,36 Because TMPRSS2 is regulated by the androgen receptor,37 it has been hypothesized that androgen depletion or blockade can be a therapeutic strategy to minimize COVID-19 illness.