The Kruskal–Wallis H test was used to compare the dynamic changes of these soluble factors in the peripheral circulation of patients with cervical cancer, and the results revealed significant differences in sHLA-G (P = 0.004), IL-6 (P = 0.002), and IL-10 (P = 0.038) levels between the initial surgery (preoperation group, postoperation group) and clinical relapse group. Here, IL6 is linked to cervical cancer.