In this study, we reported that soluble HLA-G and specific cytokines levels were associated with the carcinogenesis and progression of cervical cancer from diagnostics to prognosis, including the following findings: (i) sHLA-G and cytokines IL-6, IL-10 plasma levels had a good discriminatory effect between cervical cancer patients and healthy women, suggesting that sHLA-G could be used as a potential biomarker of cervical cancer; (ii) after surgical removal of the cervical tumour, the correlations between the different cytokines changed significantly. Here, HLA-G is linked to uterine cervix neoplasm.