The limitations of this study are as follows: (i) lack of specific functional assessments focussed on an exploration of sHLA-G/cytokines and their receptors; such analysis might help to clarify and corroborate our findings; and (ii) lack of identification of immune cell types secreting specific cytokines; assessing these cell types might help for the development of novel immunological therapeutic approaches for cervical cancer. This evidence concerns the gene HLA-G and cervical cancer.