Therefore, our results that the tau contents primarily affected the SP layer, while the Aβ contents correlated with the changes in SM/SL/SR layers in AD, supported our previous conclusion that the tau‐pathology may favorably affect the cellular structures and the Aβ‐pathology may have a larger impact on the axonal processes (Zhao et al., 2021). The gene discussed is MAPT; the disease is Alzheimer disease.