In AD, it is widely postulated that Aβ triggers tau-mediated toxicity leading to AD-type neurodegeneration in brain regions such as the hippocampus, the precuneus and posterior cingulate cortex (PCC), bilateral angular gyrus (ANG), and medial temporal lobes (Chételat et al., 2008; Misra et al., 2009; Mosconi et al., 2009; Kljajevic et al., 2014). Here, MAPT is linked to Alzheimer disease.