We therefore used RNAscope to map the expression of Tshr, Lhcgr, and Fshr in the mouse brain; immunofluorescence and qPCR to provide confirmatory evidence for Tshr and Fshr expression; and ViewRNA and qPCR to examine for FSHR expression in AD-vulnerable regions of the human brain. The gene discussed is TSHR; the disease is Alzheimer disease.