Profoundly, Yan et al and You et al,45, 46 respectively, demonstrated that the proliferation and migration of vascular smooth muscle cells (VSMCs) and HUVECs are the major composition of atherosclerotic plaques while metformin could suppress these proliferation and migration through activating different AMPK‐dependent pathways, alleviating diabetes‐accelerated AS. This evidence concerns the gene PRKAA1 and diabetes mellitus.