Pernicious mutations in KDM6A are present in many cancer types, including urothelial carcinoma, bladder cancer, renal papillary cell carcinoma, some B/T‐cell lymphomas, and squamous cell carcinomas in the lung, head, and neck [20, 62, 63, 64, 65]. Here, KDM6A is linked to papillary renal cell carcinoma.