The ‘Chimp UP’ genes include HIST1H3A, BCL2L2 and CLIC1, which have been reported to be expressed in the hippocampus and are associated with sleep, AD and neurite outgrowth (Averaimo et al., 2014; Datson et al., 2009; Wei, 2020). The gene discussed is CLIC1; the disease is Alzheimer disease.