However, compared with the I/R group, the expression of LC3 (p = 0.0482) in the I/R + Lomitapide group was significantly increased, while expression of LAMP2 (p = 0.0004) and P62 (p = 0.0074) was decreased, as shown in Figure 3A–D, suggesting that lomitapide can increase autophagy activity of neurons after cerebral infarction. The gene discussed is LAMP2; the disease is brain infarction.