SETD2 and glioblastoma: As a control, we also overexpressed H3.3G34R, which is found in glioblastoma (Schwartzentruber et al., 2012) and osteosarcoma (Behjati et al., 2013), and which inhibits both SETD2 and NSD2 only locally in cis (Fang et al., 2018; Shi et al., 2018).