As a control, we also overexpressed H3.3G34R, which is found in glioblastoma (Schwartzentruber et al., 2012) and osteosarcoma (Behjati et al., 2013), and which inhibits both SETD2 and NSD2 only locally in cis (Fang et al., 2018; Shi et al., 2018). Here, SETD2 is linked to osteosarcoma.