MTOR and amyotrophic lateral sclerosis: TOR1 has also been shown to negatively regulate autophagy and mitophagy (Liu and Okamoto, 2018), and inhibition of mTOR might have therapeutic potential in the treatment of AD, PD, ALS and HD (Ravikumar et al., 2004; Van Skike et al., 2018; Zhu et al., 2019).