As a novel and potent regulator of glucose uptake and lipid metabolism, recombinant human fibroblast growth factor 21 (rhFGF21) also downregulated NF-κB and enhanced PPAR-γ, thereby suppressing M1-like microglia polarization and expression of pro-inflammatory factors, and favoring functional recovery in experimental stroke (Wang et al., 2020). This evidence concerns the gene NFKB1 and stroke disorder.