Following cerebral ischemia, danger-associated molecular patterns, including high-mobility-group box 1 (HMGB1), peroxiredoxins, IL-33, mitochondrial transcription factor A, and cytochrome C, are released by damaged neurons in the minutes and bind to receptors on immune cells and then result in inflammation and neurotoxicity [54–56]. This evidence concerns the gene HMGB1 and Cerebral ischemia.