SARS-CoV-2 spike (S) glycoproteins induce direct cytopathic effects upon interactions with the ACE2 receptors and further downregulates ACE2 expression [43], which in turn renders this enzyme incapable of exerting its protective effects and results in dysregulated RAAS, leading to malabsorption, diarrhea, and other intestinal disorders [40, 44, 45]. This evidence concerns the gene ACE2 and intestinal disorder.