TP53 and hepatocellular carcinoma: In addition, CCK-8 data suggested that overexpression of lncRNA SAMD12-AS1 (pcDNA-SAMD12-AS1) significantly stimulated the migration and proliferation hepatocellular carcinoma cells, but overexpression of p53 significantly blocked the effect induced by overexpression of lncRNA SAMD12-AS1 (pcDNA-SAMD12-AS1) (Figures 5(b) and 5(c)).