PVT1 and colorectal carcinoma: This finding is in concordance with previous studies showing that CASC11 can play a role in CRC progression via activation of the WNT/β-catenin pathway and PVT1 by regulating the MiR-106b-5p/FJX1 axis, and knockdown of PVT1 or CASC11 suppresses the proliferation of CRC cells (19, 40).