The MAPK pathway stimulates TTP phosphorylation and becomes less active when it is phosphorylated, preventing deadenylation through the retention of 14-3-3 protein, thus failing to promote mRNA decay, leading to enhanced mRNA stability and translation and promoting the formation of cancer features, including proliferation, invasion, angiogenesis, metastasis and drug resistance (62). The gene discussed is ZFP36; the disease is cancer.