EIF4E may be an important regulator of angiogenic factor (such as IL-8 and VEGF) production in breast cancer cells, affecting angiogenesis by regulating the translation of its target mRNAs (VEGF, Cyclin D1 and FGF2), and is associated with a poor prognosis in breast cancer (114, 115). The gene discussed is CCND1; the disease is breast carcinoma.