Serine/arginine-rich splicing factors (SRS) belong to a family of serine-rich proteins, typically consisting of 12 members (SRSF1-12), that play a key role in controlling alternative splicing in cancer, for which aberrant expression of SRS, for example, leads to aberrant RNA splicing and ultimately affects tumor cell proliferation, migration and apoptosis (78). This evidence concerns the gene SMS and cancer.