EIF4E and breast cancer: CPEB1 is negatively associated with breast cancer metastasis, and mechanistically, knockdown of CPEB1 can contribute to breast cancer metastasis through polyadenylation and translation of MMP9 mRNA (66).In breast cancer, EIF4E increases mesenchymal markers by regulating its phosphorylation, which in turn promotes tumor EMT, invasion and metastasis (67).