BCL2L1 and cancer: In living cells, Sam68, when phosphorylated by Src-like kinase, alters the splicing of Bcl-x and leads to the ratio change of the two splice variants it encodes, pro-apoptotic Bcl-x(S) and anti-apoptotic Bcl-x(L), which facilitates the accumulation of Bcl-x(L) and thus keeps cancer cells from undergoing apoptosis (82).