LARP7 is expressed at low levels in invasive breast cancer tissues and cells; therefore, when a reduction in LARP7 expression is observed, P-TEFb (positive transcriptional elongation factor b) in 7SK snRNP is released, and P-TEFb is reassigned to the transcriptionally active super elongation complex, allowing P-TEFb activation and EMT transcription factors (including FOXC2, Slug Twist1 and ZEB2) to be transcriptionally increased, which ultimately promotes breast cancer invasion, metastasis and EMT (60). Here, TWIST1 is linked to breast carcinoma.