Eukaryotic translation initiation factor 4E (EIF4E), one of the components of the translation initiation complex EIF4F, recognizes and binds the m7G cap at the 5’ end of mRNA and is a key factor in initiating translation, while its phosphorylation increases mesenchymal markers such as N-calmodulin, wave proteins and fibronectin, which in turn promote tumor invasion, EMT and metastasis (67). Here, EIF4E is linked to neoplasm.