Complicating a clear understanding of the role of O-GlcNAcylation in the EMT of endometrial cancer, hyper-O-GlcNAcylation is associated with increased E-cadherin and decreased SNAIL expression, and O-GlcNAcylation status had no impact on the expression of the EMT markers Vimentin, SLUG, and ZEB1 (57). This evidence concerns the gene SNAI1 and endometrial cancer.