In vitro study, we further explore the function of CDKN2A in the formation of hNiT structures and disclosed that CDKN2A could inhibit the hNiT formed by tumor cells internalizing neutrophils, which was reminiscent of the parallel role of CDKN2A in the homotypic cell-in-cell structures formation (4). The gene discussed is CDKN2A; the disease is neoplasm.