A class of Bisindole-derived (CDIMs) NR4A1 antagonists, such as 1,1-bis(3’-indolyl)-1-(p-hydroxyphenyl) methane (DIM-C-pPhOH), can decrease the expression of NR4A1 in breast, lung, and liver cancer cells to inhibit tumor growth, EMT and stemness (97, 98). Here, NR4A1 is linked to liver cancer.