PKM and hepatocellular carcinoma: Another research reported that by binding to the promoter of WAP four-disulfide core domain 21 pseudogene (WFDC21P), NR4A1 also inhibited two key glycolysis enzymes, the platelet-type PFK (PFKP) and the M2 isoform of pyruvate kinase (PKM2), to suppress the HCC cell proliferation and tumor metastasis (49).