(54, 55) reported the relationship between enhanced glycolysis and the aberrant activation of β-catenin, while our previous study confirmed that β-catenin and NR4A1 could form a mutually feedback control circuit to promote CRC invasion, demonstrating that NR4A1 may be involved in the glycolysis in colorectal cancer. The gene discussed is NR4A1; the disease is colorectal cancer.